38. G. Wang, F. Venegas, A. Rueda, N. Weerasinghe, K. A. Uggowitzer, C. J. Thibodeaux, N. Moitessier, A. K. Mittermaier, A naturally occurring G11S mutation in the 3C-like protease from the SARS-CoV-2 virus dramatically weakens the dimer interface, Protein Sci. 2023, e4857.

37.  C. J. Thibodeaux, The Conformationally Dynamic Structural Biology of Lanthipeptide Biosynthesis, Curr. Opin. Struct. Biol. 2023, 81, 102644.

36.      A. Saran, N. Weerasinghe, C. J. Thibodeaux, and N. Zeytuni, Purificaiton, Crystallizaiton, and Preliminary Crystallographic Analysis of the PorX Reponse Regulator Associated with the Type-IX Secretion System.  Acta Crystallographica Section F. 2023, F78, 354-362.       

35.      K. Uggowitzer, A. R. Q. Shao, Y. Habibi, Q. E. Zhang, and C. J. Thibodeaux, Exploring the Heterogeneous Structural Dynamics of Class II Lanthipeptide Synthetases with Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS), Biochemistry. 2022 61, 2118-2130.

34.      C. Lemay-St-Denis, L. Alejaldre, Z. Jemouai, K. Lafontaine, M. St-Aubin, K. Hitache, D. Valhikani, N. W. Weerasinghe, M. Létourneau, C. J. Thibodeaux, N. Doucet, C. Baron, J. N. Copp, J. N. Pelletier, A conserved SH3-like fold in structurally diverse putative proteins tetramerizes into a functional oxidoreductase providing an antimicrobial resistance phenotype.  Phil. Trans. Royal Soc. B., under review.

33.      Y. Habibi, N. Weerasinghe, K. Uggowitzer, and C. J. Thibodeaux.  Partially-Modified Peptide Intermediates in Lanthipeptide Biosynthesis Alter the Structure and Dynamics of a Lanthipeptide Synthetase.  J. Am. Chem. Soc. 2022, 144, 10230-10240.

32.      S. Hamry and C. J. Thibodeaux. Biochemical and Biophysical Investigation of the HalM2 Lanthipeptide Synthetase using Mass Spectrometry. Can. J. Chem. 2022, 100, 182-196.

31.      J. Ducharme, I. F. Sevrioukova, C. J. Thibodeaux, K. Auclair*. Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase.  Biochemistry 2021, 60, 2259-2271.     

30.      N. W. Weerasinghe, Y. Habibi, K. A. Uggowitzer, and C. J. Thibodeaux. Exploring the Conformational Landscape of a Lanthipeptide Synthetase using Native Mass Spectrometry. Biochemistry 2021, 60, 1506-1519.

29.      J. Ducharme, C. J. Thibodeaux, and K. Auclair.* Combining small-molecule bioconjugation and hydrogen-deuterium exchange mass spectrometry (HDX-MS) to expose allostery: the case of human cytochrome P450 3A4.  ACS Chem. Biol. 2021, 16, 882-890.

28.      K. Uggowitzer, Y. Habibi, W. Wei, N. Moitessier, and C. J. Thibodeaux.  Mutations in Dynamic Structural Elements Alter the Kinetics and Fidelity of the Multifunctional Class II Lanthipeptide Synthetase, HalM2.  Biochemistry 2021, 60, 412-430.

27.      S. Moussa, M. R. Van Horn, A. Shah, L. Pollegioni, C. J. Thibodeaux, E. S. Ruthazer, J. Mauzeroll. A Miniaturized Enzymatic Biosensor for Detection of Sensory-Evoked d-serine Release in the Brain.  J. Electrochem. Soc. 2021, 168, 025502.

26.      Mohamed A. Attia and C. J. Thibodeaux. Cycling Back to Biocatalysis.  Nat. Catal. 2020, 3, 476-477.

25.      T. Priemel, R. Palia, M. Babych, C. J. Thibodeaux, S. Bourgault, M. J. Harrington.  Compartmentalized processing of catechols during mussel byssus fabrication determines the destiny of DOPA.Proc. Natl. Acad. Sci. U.S.A. 2020, 117, 7613-7621.

24.      Y. Habibi and C. J. Thibodeaux. A Workflow for Studying the Structural Dynamics of Biosynthetic Enzymes using Hydrogen-Deuterium Exchange Mass Spectrometry. J. Vis. Exp. 2020, 159, e61053, doi:10.3791/61053.

23.      Y. Habibi, K. Uggowitzer, H. Issak, and C. J. Thibodeaux. Insights into the Dynamic Structural Properties of a Lanthipeptide Synthetase using Hydrogen-Deuterium Exchange Mass Spectrometry. J. Am. Chem. Soc. 2019, 141, 14661-14672.

22.      C. J. Thibodeaux, W.-C. Chang, and H.-w. Liu. Unraveling Flavoenzyme Reaction Mechanisms using Flavin Analogues and Linear Free Energy Relationships. Methods Enzymol., 2019, 617, 167-188.

21.      C. J. Thibodeaux and H.-w. Liu. The Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase (IDI-2): A Model for Acid/Base Chemistry in Flavoenzyme Catalysis. Arch. Biochem. Biophys. 2017, 632, 47-58.

20.      C. J. Thibodeaux, J. Wagoner, Y. Yu, W. A. van der Donk. Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis. J. Am. Chem. Soc. 2016, 138, 6436-6444.

19.      K. S. Ju, J. Gao, J. R. Doroghazi, K. K. Wang, C. J. Thibodeaux, S. Li, E. Metzger, J. Fudala, J. Su, J. K. Zhang, J. Lee, J. P. Cioni,, B. S. Evans, R. Hirota, D. P. Labeda, W. A. van der Donk, W. W. Melcalf. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proc. Natl Acad. Sci. U.S.A. 2015, 112, 12175-12180.

18.      C. J. Thibodeaux, T. Ha and W. A. van der Donk.  A price to pay for relaxed substrate specificity: A comparative kinetic analysis of the class II lanthipeptide synthetases, HalM2 and ProcM. J. Am. Chem. Soc. 2014, 136, 17513-17529.

17.      C. J. Thibodeaux and W. A. van der Donk. Converging on a mechanism for choline degradation.  Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 21184-21185.

16.      H.-w. Liu, C. J. Thibodeaux, J. Calveras, W.-c. Chang. Determining the Role of the Reduced FMN Coenzyme in the Reaction Catalyzed by the Type II Isopentenyl Diphosphate:Dimethylally Diphosphate Isomerase (IDI-2) in Proceedings of the 17th International Symposium of Flavins and Flavoproteins. S. Miller, R. Hill, B.. Palfey, and G. Cecchini, Eds., Alan R. Liss: New York, pp. 21-32, 2013.

15.      J. Calveras, C. J. Thibodeaux, S. O. Mansoorabadi, and H.-w. Liu.  Stereochemical studies of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase implicate the FMN coenzyme in substrate protonation. ChemBioChem 2012, 13, 42-46.

14.      C. J. Thibodeaux, W.-c. Chang, and H.-w. Liu. The enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis. Chem. Rev. 2012, 112, 1681-1709.

13.      H. G. Sun, M. W. Ruszczycky, W.-c. Chang, C. J. Thibodeaux, and H.-w. Liu.  Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase.  J. Biol. Chem. 2012, 287, 4602-4608.

12.      C. J. Thibodeaux and H.-w. Liu. Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: Characterization of an unusual pyridoxal 5′-phosphate-dependent reaction. Biochemistry 2011, 50, 1950-1962.

11.      C.J. Thibodeaux, W.-c. Chang, H.-w. Liu.  Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase. J. Am. Chem. Soc. 2010, 132, 9994-9996.

10.      J. White-Phillip, C. J. Thibodeaux, and H.-w. Liu. Enzymatic synthesis of TDP-deoxysugars. Meth. Enzymol. 2009, 459, 521-544.

9.         C. J. Thibodeaux and H.-w. Liu. Unraveling the mechanisms of isoprenoid biosynthetic enzymes: Mechanistic studies of the early stage enzymes. Chimia 2009, 63, 1-6.

8.         C. J. Thibodeaux, S. O. Mansoorabadi, W. Kittleman, W.-c. Chang, H.-w. Liu. Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Staphylococcus aureus.  Biochemistry 2008, 47, 2547-2558.

7.         C. J. Thibodeaux, C. E. Melancon III, and H.-w. Liu. Natural product sugar biosynthesis and enzymatic glycodiversification. Angew. Chem. Int. Ed. 2008, 47, 9814-9859.

6.         S. O. Mansoorabadi, C. J. Thibodeaux, and H.-w. Liu.  The diverse roles of flavin coenzymes – Nature’s most versatile thespians. J. Org. Chem. 2007, 72, 6329-6342.

5.         C. J. Thibodeaux, and H.-w. Liu. Manipulating Nature’s sugar biosynthetic machineries.  Pure. Appl. Chem. 2007, 79, 785-799.

4.         W. Kittleman, C.J. Thibodeaux, Y.-n. Liu, H. Zhang, H.-w. Liu.  Characterization and mechanistic studies of type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Staphylococcus aureus. Biochemistry 2007, 46, 8401-8413.

3.         C. J. Thibodeaux, C. E. Melancon III, and H.-w. Liu. Unusual sugar biosynthesis and natural product glycodiversification.  Nature 2007, 446, 1008-1016.

2.         C. J. Thibodeaux, H.-w. Liu, and J.S. Thorson.  Complementary routes to natural product glycodiversification: Pathway engineering and glycorandomization in Comprehensive Glycoscience. 2007, Vol 3 of 4, J. Kamerling, G.-J. Boons, Y. Lee, A. Suzuki, N. Taniguchi, A. G. J. Voragen, Eds. Elsevier: pp 373-396.

1.         C. E. Melancon III, C. J. Thibodeaux, and H.-w. Liu. Glyco-stripping and Glyco-swapping.  ACS Chem. Biol. 2006, 1, 499-504.